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Ke-Hui Cui M.D., Ph.D.

Savannah, Georgia, 31405, U.S.A.

Nov. 7, 2016

Email: khcui72@hereditics.net

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*Comment for "'Three-person babies' grow up into healthy teenagers", ivf.net, Nov. 1,  2016.

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In this news report, it said: “All couples who took part in the original study were at risk of passing on a mitochondrial disease to their children if they had been conceived naturally…” This is not the case in Dr. Jacques Cohen’s paper published in 1998: “All the patient couples concerned had experienced multiple assisted reproductive cycles with implantation failure attributable to poor embryo development.” The above discrepancy showed that Dr. Cohen had a feeling of guilt and wished to hide the misleading fact reported in 1998. Nowadays, a lot of IVF centers can easily achieve 100% pregnancy by up to three cycles for a couple who wish to have a child without the complicated animal techniques - mitochondrial replacement techniques (MRT). Most embryologists recently know that Dr. Cohen’s claim in 1998 is totally misleading. In this report, Dr. Cohen’s credit and the credit of the whole “Healthy” report are questionable. Seventeen children were all mature. However, only the health data of 13 children were reported. The distorted and hid data from these 13 children and another 4 children are highly possible. Scientific design of the project related to heredity for animal should have control and experiment groups each contains more than 50 cases with up to at least 10 generations to show the offspring and further offspring and offspring, etc. are the same as the control. This report showed most of the three-parent children with all kinds of healthy problems which will not happen in so high incidence in normal children of human beings. To use this report to claim “healthy”, “done well” or “safe” is not scientific but misleading and not responsible in design, method, results and conclusion. Intolerable ethical background of MRT makes further producing three-parent children and collecting the whole and creditable data to be not possible, thus the “safety” issue of MRT in human will be lack of a conclusion forever. To use premature and misleading “safe” presumption to put pressure on FDA, congress and human society to change human beings is hopeless forever.

 

MRT produces “three-parental” children is the smoothest saying, which was created by Dr. Cohen to hide the severity of MRT. The key issue of MRT is that MRT changes human beings in heredity or genetics. Any primary and middle school student understands that human beings develop naturally for million years and are the most precious in the world. And they should not treat human as animals. In Dr. Cohen’s (1998) paper, he quoted a lot of animal research papers to confirm his reasonability to perform MRT in human only for the aim of pregnancy. He put animal science as human science. He treated human as animals, and change human heredity as changing animal heredity. It showed that Dr. Cohen is a pseudoscientist in human reproductive medicine. A human scientist should differentiate the difference between human and animal, between human science and animal science. Without ability to differentiate the said difference means not understand human science. There is no ethics between animal and animal. However, there is ethics in human beings. The most important thing in human beings is dignity of human heredity. Dr. Cohen changed the human oocyte gene, and let the babies with three-person genes. That is to change normal human beings to be not human beings, but sub-human beings. That challenge the dignity of human beings in heredity. Without correctly understand human ethics, people are not qualified to work in the field of human medicine, especially in the field of reproductive medicine. Francis Collins, director of NIH stated that “concept of altering the human germline in embryos for clinical purposes has been debated over many years from many different perspectives, and has been viewed almost universally as a line that should not be crossed” (NIH, 2015). The simple reason is: the gene modifications would be passed on to future generations forever.

 

Why do Dr. Cohen, Dr. John Zhang, businessmen in OvaSciences, Sir Dr. Winston (in London Hammersmith Hospital, promoter of MRT for British Congress) and so many related media have a “symphony” for MRT in human beings to change gene, and at last to change the whole human beings? Everyone answers: for money. These pseudoscientists and some media use the most beautiful things to attract our patients and a lot new scientists: baby and healthy babies. Although there are many simple methodologies can achieve the same aim without the results to change human beings in heredity, they still mislead people and patients that they have the most advanced techniques to serve the patients. They have misled people for many years, and their way was workable for them. “Healthy babies” is only a card for the pseudoscientists to get more money. The dignity of human beings and the true health of the babies are not their aim.

 

These pseudoscientists said MRT leads to more ATP (energy) for embryo survival. However, MRT could not let the dying or ill (apoptosis) eggs survive well and produce healthier babies. They knew cytoplasm but ignored the health of nuclear DNA. They do not have enough basic knowledge to understand germline biology and physiopathology. When an egg was lack of energy during growth and meiosis, some of its nuclear DNA has already mutated, deformed or changed the condition of methylation and other epigenetic condition. No one in the world can diagnose the whole genomic condition of the specific egg and use the same egg to produce a healthy baby now and in future. The babies produced by MRT are from those eggs on the borderline of survival which would have some kinds of changes already in the nuclear DNA. Those babies with the alteration of their nuclear DNA from MRT will never be healthier than the natural human babies, not mention to the toxic function of the external mitochondria, or the disturbance and disruption of the microtubules (which connecting nuclear DNA) by the harmful animal technique – spindle or pronuclear transfer using on human eggs.

 

The three-parent children will someday ask their parent: “I and my offspring do not wish to be three-parent children anymore. Can you ask those doctors to change me back to be two-parent child?” Mother will tell them: “Not possible in science.” The three-parent children will be very upset. They will said: “I do not have any true friends in all of my life because I can not tell them the truth of mine. I will sue those pseudoscientists, their related reporters and organization to the international court. They are criminals in changing human heredity. They are traitors of human beings. Put them in jail. Ask them to repay all of my damage: from my health, my dignity, my loss of job, my loss of future family, to… etc.”

 

Court will judge.

 

Please also read “HUMAN BEINGS SHOULD NOT BE CHANGED IN HEREDITY” published on ivf.net 18 October 2016 comment for “Mitochondrial replacement therapy and the welfare of the child” response on 02 November 2016.

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